Title of article
A novel approach to Finafloxacin hydrochloride (BAY35-3377)
Author/Authors
Hong، نويسنده , , Jian and Zhang، نويسنده , , Zonghua and Lei، نويسنده , , Huoxing and Cheng، نويسنده , , Haiying and Hu، نويسنده , , Yufang and Yang، نويسنده , , Wanliang and Liang، نويسنده , , Yinglin and Das، نويسنده , , Debasis and Chen، نويسنده , , Shu-Hui and Li، نويسنده , , Ge، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
2525
To page
2528
Abstract
Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 19 was prepared by a new route. The chiral (S,S′)-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis.
Keywords
Finafloxacin hydrochloride , BAY35-3377 , Fluoroquinolone antibiotics
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1863747
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