Author/Authors :
Gonzلlez، نويسنده , , Alfredo and Pérez، نويسنده , , Daniel and Puig، نويسنده , , Carles and Ryder، نويسنده , , Hamish and Sanahuja، نويسنده , , Jordi and Solé، نويسنده , , Laia and Bach، نويسنده , , Jordi، نويسنده ,
Abstract :
A practical and efficient three-step sequence for the deamination of α-aminoesters is reported. This method is based on the NaBH4-mediated selective reduction of α-diazoesters to α-hydrazonoesters and has been successfully applied to the deamination of several representative α-aminoesters including some l-cysteine ethyl ester derivatives, key intermediates in the synthesis of a series of CysLT1 antagonists.
Keywords :
?-Hydrazonoesters , Reduction , ?-Aminoesters , ?-Diazoesters , deamination , CysLT1 antagonists
