Title of article :
Multicomponent approach to unique 1,4-diazepine-2-amines
Author/Authors :
Kysil، نويسنده , , Volodymyr and Khvat، نويسنده , , Alexander and Tsirulnikov، نويسنده , , Sergey E. Tkachenko، نويسنده , , Sergey and Ivachtchenko، نويسنده , , Alexandre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Isocyanide-based multicomponent reaction (IMCR) of 1,3-diaminopropane with carbonyl compounds has been developed as an efficient strategy for the synthesis of 1,4-diazepine-2-amines. Brّnsted and Lewis acids are able to promote the reaction, and TMSCl has been found to be the most efficient among them. The IMCR is applicable to a variety of carbonyl compounds and isocyanides.
Keywords :
Isocyanide-based multicomponent reaction (IMCR) , 1 , 4-Diazepine-2-amine , 1 , Trimethylchlorosilane (TMSCl) , Spiro-compounds , 4-Diazepine ring synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
