Title of article :
A tandem decarboxylation and inverse electron-demand Diels–Alder reaction of amino-thiophenecarboxylic acids with 1,3,5-triazines
Author/Authors :
Dang، نويسنده , , Qun and Carruli، نويسنده , , Edmund and Tian، نويسنده , , Feng and Dang، نويسنده , , Francis W. and Gibson، نويسنده , , Tony and Li، نويسنده , , Wenyu and Bai، نويسنده , , Huachen and Chung، نويسنده , , Michael and Hecker، نويسنده , , Scott J.، نويسنده ,
Abstract :
The scope of 1,3,5-triazine inverse electron-demand Diels–Alder (IDA) reactions was expanded to include aminothiophenecarboxylic acids as latent dienophiles. A series of 2-amino-3-thiophenecarboxylic acids (1a–d) and a 3-amino-2-thiophenecarboxylic acid (5) were introduced as productive dienophiles in IDA reactions with various 1,3,5-triazines (2a–e). This method is useful for the one-step synthesis of both thieno[2,3-d]pyrimidines and thieno[3,2-d]pyrimidines, which should complement existing methods.
