Author/Authors :
Clark، نويسنده , , Ryan C. and Lee، نويسنده , , Sang Yeul and Hwang، نويسنده , , Inkyu and Searcey، نويسنده , , Mark and Boger، نويسنده , , Dale L.، نويسنده ,
Abstract :
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
