Author/Authors :
Ishida، نويسنده , , Hiroshi and Carrillo، نويسنده , , Nancy and Bode، نويسنده , , Jeffrey W.، نويسنده ,
Abstract :
The synthesis of an enantiopure isoxazolidine monomer for the incorporation of β3-aspartic acid residues into β3-oligopeptides via chemoselective α-ketoacid–hydroxylamine amide formation is disclosed. This route involves nitrone cycloaddition of 3-thiophenylpropanal and circumvents limitations of other potential starting materials.
