Author/Authors :
Deimante Cerniauskaite، نويسنده , , Deimante and Gallienne، نويسنده , , Estelle and Karciauskaite، نويسنده , , Henreta and Farinha، نويسنده , , Andrea S.F. and Rousseau، نويسنده , , Jolanta and Armand، نويسنده , , Sylvie and Tatibouët، نويسنده , , Arnaud and Sackus، نويسنده , , Algirdas and Rollin، نويسنده , , Patrick، نويسنده ,
Abstract :
New non-hydrolyzable analogues of glucosinolates have been prepared. Myrosinase inhibition was observed with modified aglycon moieties, even bulky phenothiazine analogue 6 gave reasonable inhibition. The simplest structure 8 derived from dimethylaminoethanethiol has shown to be the most potent inhibitor with an IC50 of 3.32 μM.
Keywords :
glucosinolate , Myrosinase inhibition , sulfation , Thiohydroximate
