Author/Authors :
Aggarwal، نويسنده , , Varinder K. and Barbero، نويسنده , , Nekane and McGarrigle، نويسنده , , Eoghan M. and Mickle، نويسنده , , Greg and Navas، نويسنده , , Raquel and Suلrez، نويسنده , , José Ramَn and Unthank، نويسنده , , Matthew G. and Yar، نويسنده , , Muhammad، نويسنده ,
Abstract :
Ellman’s chiral auxiliary is converted into tert-butylsulfinyl chloride on sulfinamide deprotection with HCl and can be recovered in high yield upon treatment with ammonia. The enantiopure auxiliary can be obtained by trapping the sulfinyl chloride with a chiral alcohol followed by treatment of the resulting sulfinate ester with LiNH2.
Keywords :
tert-butylsulfinamide , sulfinimines , Deprotection , dynamic kinetic resolution , cleavage , Ellman’s auxiliary
