Title of article
First total synthesis of theopederin B
Author/Authors
Nishii، نويسنده , , Yoshinori and Higa، نويسنده , , Tsuyoshi and Takahashi، نويسنده , , Shunya and Nakata، نويسنده , , Tadashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
3597
To page
3601
Abstract
Total synthesis of theopederin B, isolated from marine sponge, was accomplished by coupling pederic acid, as the left half, with trioxodecaline amine as the right half. Key reactions for synthesizing the amine were SmI2-promoted Reformatsky reaction, stereoselective allylation followed by Sharpless asymmetric epoxidation for construction of the functionalized side chain, and 1,3-dioxane ring construction followed by azide insertion.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864531
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