Title of article :
1,4-Dehydrochlorination of 1-(1-haloalkyl)-3,4-dihydroisoquinolines as a convenient route to functionalized isoquinolines
Author/Authors :
Jacobs، نويسنده , , Jan and Van، نويسنده , , Tuyen Nguyen and Stevens، نويسنده , , Christian V. and Markusse، نويسنده , , Peter and De Cooman، نويسنده , , Paul and Maat، نويسنده , , Leendert and De Kimpe، نويسنده , , Norbert، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
1-Chloroalkyl-, 1-(2,2-dichloroalkyl)-, and 1-(trichloromethyl)-3,4-dihydroisoquinolines are synthesized by chlorination of 1-alkyl-3,4-dihydroisoquinolines with N-chlorosuccinimide. These novel chlorinated 3,4-dihydroisoquinolines are suitable precursors for functionalized isoquinolines by aromatization involving sequential 1,4-dehydrochlorination, tautomerization, and nucleophilic substitution.
Keywords :
Halogenated 3 , 4-Dihydroisoquinolines , Isoquinolines , 1 , 4-Dehydrochlorination
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
