Title of article :
Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors
Author/Authors :
Jerome، نويسنده , , Laure and Sheppard، نويسنده , , Tom D. and Aliev، نويسنده , , Abil E. and Motherwell، نويسنده , , William B.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Intramolecular amidocyclopropanation reactions of diethoxymethyl-lactams containing a pendant alkene were examined using zinc/TMSCl. With a range of 4–6-membered lactams, bicyclic amidocyclopropanes were obtained with very high diastereoselectivity with a preference for the formation of the more hindered endo-cyclopropane.
Keywords :
carbenoids , lactams , Cyclopropanes , Zinc , alkenes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
