Author/Authors :
Dيaz-Oltra، نويسنده , , Santiago and Angulo-Pachَn، نويسنده , , César A. and Kneeteman، نويسنده , , Marيa N. and Murga، نويسنده , , Juan and Carda-Broch، نويسنده , , Miguel and Marco-Castaٌo، نويسنده , , J. Alberto، نويسنده ,
Abstract :
A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure.
Keywords :
Macrolides , Mukaiyama C-glycosidation , Aspergillides , Yamaguchi macrolactonization , Brown asymmetric allylation , Cross metathesis
