Title of article :
Pd/C–Cu in coupling-cyclization process: a general synthesis of 2-substituted 6-oxopyrrolo[3,2,1-ij]quinoline derivatives
Author/Authors :
Layek، نويسنده , , Mohosin and Gajare، نويسنده , , Vikas and Kalita، نويسنده , , Dipak and Islam، نويسنده , , Aminul and Mukkanti، نويسنده , , K. and Pal، نويسنده , , Manojit، نويسنده ,
Abstract :
A general and practical synthesis of 2-substituted 6-oxopyrrolo[3,2,1-ij]quinolines has been achieved following a single-step Pd/C-mediated coupling-cyclization strategy. The methodology involves the reaction of 8-iodo-4-oxo-1,4-dihydro quinoline-3-carboxylic acid ethyl ester with a variety of terminal alkynes in the presence of 10% Pd/C–PPh3–CuI as a catalyst system in EtOH. The reaction mechanism and utility of the methodology have been discussed.
