Author/Authors :
Song، نويسنده , , Jinhua J. and Tan، نويسنده , , Zhulin and Reeves، نويسنده , , Jonathan T. and Fandrick، نويسنده , , Daniel R. and Lee، نويسنده , , Heewon and Yee، نويسنده , , Nathan K. and Senanayake، نويسنده , , Chris H.، نويسنده ,
Abstract :
Treatment of unprotected 5-amino-4-methylpyrimidine (2) with n-BuLi gave dianion 3. Direct condensation of the dianion with various carboxylic acid derivatives furnished a range of 2-substituted-4,6-diazaindoles in good yields in one step without the need for protecting groups or oxidation-state adjustment.
