Author/Authors :
Shannon Fix-Stenzel، نويسنده , , Shannon R. and Hayes، نويسنده , , Martin E. and Zhang، نويسنده , , Xiaolei and Wallace، نويسنده , , Grier A. and Grongsaard، نويسنده , , Pintipa and Schaffter، نويسنده , , Lisa M. and Hannick، نويسنده , , Steven M. and Franczyk، نويسنده , , Thaddeus S. and Stoffel، نويسنده , , Robert H. and Cusack، نويسنده , , Kevin P.، نويسنده ,
Abstract :
A scalable and enantioselective synthesis of a potent S1P1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyzed alkylation protocol, allows for substrate directed hydrogenation to install the second stereogenic center providing access to gram-quantities of compound 2.
