Title of article :
Convergent synthesis of oligomers of triazole-linked DNA analogue (TLDNA) in solution phase
Author/Authors :
Fujino، نويسنده , , Tomoko G Yamazaki، نويسنده , , Naomi and Isobe، نويسنده , , Hiroyuki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA (TLDNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer TLDNA in good yield.
Keywords :
click chemistry , Artificial oligonucleotide , Convergent synthesis , Solution-phase synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
