Title of article
Convergent synthesis of oligomers of triazole-linked DNA analogue (TLDNA) in solution phase
Author/Authors
Fujino، نويسنده , , Tomoko G Yamazaki، نويسنده , , Naomi and Isobe، نويسنده , , Hiroyuki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4101
To page
4103
Abstract
A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA (TLDNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer TLDNA in good yield.
Keywords
click chemistry , Artificial oligonucleotide , Convergent synthesis , Solution-phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864905
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