Author/Authors :
Darinka Sakac، نويسنده , , Marija N. and Gakovi?، نويسنده , , Andrea R. and Csan?di، نويسنده , , J?nos J. and Djurendi?، نويسنده , , Evgenija A. and Klisuri?، نويسنده , , Olivera and Koji?، نويسنده , , Vesna and Bogdanovi?، نويسنده , , Gordana and Penov Ga?i، نويسنده , , Katarina M.، نويسنده ,
Abstract :
A novel synthetic route is reported for the preparation of steroidal triazoles via intramolecular 1,3-dipolar cycloaddition of a steroidal 16,17-seco-17-diazo-16-nitrile system. The structures of the products are established by X-ray and NMR studies. The in vitro antiproliferative activity of the steroidal triazoles against three tumor cell lines was evaluated.
Keywords :
Dipolarophiles , Steroidal triazoles , 1 , In vitro cytotoxicity , Nitriles , 3-dipolar cycloaddition
