Title of article :
Stereoselective syntheses of 11-α-methoxycurvularin and 11-β-methoxycurvularin
Author/Authors :
Venkateswar Reddy، نويسنده , , G. and Sateesh Chandra Kumar، نويسنده , , R. and Suresh Babu، نويسنده , , K. and Madhusudana Rao، نويسنده , , J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A stereoselective synthesis of potent cytotoxic macrolides, 11-α-methoxycurvularin and 11-β-methoxycurvularin has been accomplished. The synthesis entailed Maruoka asymmetric allylation to introduce the stereocentres at C-11 and the key fragment was installed by using Grubbs cross-metathesis followed by CBS-reduction.
Keywords :
Macrolides , Maruoka asymmetric allylation , Grubbs cross-metathesis , CBS-reduction , Curvularins
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
