Title of article
Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1α,25-dihydroxyvitamin D3
Author/Authors
De Buysser، نويسنده , , Frederik and Verlinden، نويسنده , , Lieve and Verstuyf، نويسنده , , Annemieke and De Clercq، نويسنده , , Pierre J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
4174
To page
4177
Abstract
In search of analogs of 1α,25-dihydroxyvitamin D3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way.
Keywords
Spirocyclic decanones , Calcitriol analogs , enantioselective synthesis
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1864965
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