Author/Authors :
Jonnalagadda، نويسنده , , Subash C. and Cruz، نويسنده , , Jonathan S. and Connell، نويسنده , , Ryan J. and Scott، نويسنده , , Patricia M. and Mereddy، نويسنده , , Venkatram R. Atigadda، نويسنده ,
Abstract :
Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.
Keywords :
multicomponent reactions , Isonitriles , Carboranes , low-density lipoprotein , boron neutron capture therapy
