Author/Authors :
Lamazzi، نويسنده , , Christelle and Dreau، نويسنده , , Armelle and Bufferne، نويسنده , , Christel and Flouzat، نويسنده , , Christine and Carlier، نويسنده , , Patrick and ter Halle، نويسنده , , Rob and Besson، نويسنده , , Thierry، نويسنده ,
Abstract :
The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloronicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile (4), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive ‘ionic alkylating intermediate’ formed in situ under microwave conditions is proposed to explain the results observed.
