Title of article
Organocatalytic synthesis of quaternary stereocenter bearing a fluorine atom: enantioselective conjugate addition of α-fluoro-β-ketoesters to nitroalkenes
Author/Authors
Oh، نويسنده , , Yeonock and Kim، نويسنده , , Sun-Mi and Kim، نويسنده , , Dae Young، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
4674
To page
4676
Abstract
The catalytic enantioselective conjugate addition reaction of α-fluoro-β-ketoesters to nitroalkenes promoted by chiral bifunctional organocatalysts is described. The treatment of α-fluoro-β-ketoesters with nitroalkenes under mild reaction conditions afforded the corresponding Michael adducts containing a fluorinated quaternary stereogenic center with excellent enantioselectivity (up to >99% ee).
Keywords
bifunctional organocatalyst , Nitroalkenes , ?-Fluoro-?-ketoesters , Asymmetric catalysis , Michael reaction
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865341
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