Title of article :
A straightforward synthesis of 1,3-dichloro-5,8-dihydroisoquinoline by consecutive Stille cross-coupling and metathesis reactions
Author/Authors :
van den Hoogenband، نويسنده , , Adri and den Hartog، نويسنده , , Jack A.J. and Faber-Hilhorst، نويسنده , , Nancy and Lange، نويسنده , , Jos H.M. and Terpstra، نويسنده , , Jan Willem، نويسنده ,
Abstract :
An efficient three-step synthetic route from 2,6-dichloro-4-iodopyridine to 1,3-dichloro-5,8-dihydroisoquinoline is described. A ring-closing-metathesis reaction constitutes the key step in this synthetic sequence. The reactivity of both chloro atoms is demonstrated in a Suzuki arylation reaction.
