Title of article
Alternative route towards the convergent synthesis of a human purine nucleoside phosphorylase inhibitor—forodesine HCl
Author/Authors
Kamath، نويسنده , , Vivekanand P. and Xue، نويسنده , , Jie and Juarez-Brambila، نويسنده , , Jesus J. and Morris Jr.، نويسنده , , Philip E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
5198
To page
5200
Abstract
Forodesine HCl is being investigated as a potential target for the control of T-cell proliferation. Herein we present an alternative route for the synthesis of the target molecule with addition of lactam to the lithiated deazahypoxanthine (generated in situ). The lactam was synthesized in five steps starting from l-pyroglutamic acid.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865710
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