Title of article :
Microwave-assisted synthesis of substituted 2-amino-1H-imidazoles from imidazo[1,2-a]pyrimidines
Author/Authors :
Ermolat’ev، نويسنده , , D.S. and Svidritsky، نويسنده , , E.P. and Babaev، نويسنده , , E.V. and Van der Eycken، نويسنده , , E.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
An efficient method for the synthesis of mono- and disubstituted 2-amino-1H-imidazoles via microwave-assisted hydrazinolysis of substituted imidazo[1,2-a]pyrimidines is reported. This protocol avoids strong acidic conditions and is superior to the classical cyclocondensation of α-haloketones with N-acetylguanidine.
Keywords :
Microwave-assisted reaction , Hydrazinolysis , ring cleavage , Substituted 2-amino-1H-imidazoles , 2-a]pyrimidines
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
