Title of article
Synthesis and conformational analysis of α,α-difluoroalkyl heteroaryl ethers
Author/Authors
Horne، نويسنده , , Daniel B. and Bartberger، نويسنده , , Michael D. and Kaller، نويسنده , , Matthew R. and Monenschein، نويسنده , , Holger and Zhong، نويسنده , , Wenge and Hitchcock، نويسنده , , Stephen A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
5452
To page
5455
Abstract
We report the efficient synthesis of difluoroalkyl aryl ethers from the rearrangement of heteroaryl ketones and aldehydes, mediated by xenon difluoride and HF/pyridine in methylene chloride at room temperature. Computational analysis of difluoroalkylethers shows that there is potential to allow access to conformational space not accessible to the hydrogenated parent.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865900
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