Title of article :
Three-component synthesis of functionalized five-membered ring lactones under Barbier-like conditions
Author/Authors :
Floch، نويسنده , , Camille Le and Bughin، نويسنده , , Carine and Gall، نويسنده , , Erwan Le and Léonel، نويسنده , , Eric and Martens، نويسنده , , Thierry، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Five-membered ring lactones have been synthesized using a straightforward three-component reaction among in situ-generated arylzinc reagents, dimethyl itaconate and aromatic aldehydes. This Barbier-like procedure, which is characterized by its simplicity, allows the concise synthesis of a range of highly functionalized 4,5-substituted γ-butyrolactones.
Keywords :
multicomponent reactions , Barbier-like conditions , ?-butyrolactones , Aryl bromides , Aromatic aldehydes , dimethyl itaconate
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
