Title of article :
Aromatization and chemoselective alkylation of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid and its derivatives
Author/Authors :
Brahmbhatt، نويسنده , , Keyur G. and Ahmed، نويسنده , , Nafees and Singh، نويسنده , , Inder P. and Bhutani، نويسنده , , Kamlesh K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Unprecedented aromatization was observed during N-alkylation reactions of 1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid methyl ester, giving rise to 9-alkyl-1-methyl-β-carboline-3-carboxylic acid methyl esters. Inverse addition of base during a similar reaction resulted in a chemoselective alkylation to form novel 3-butyl-1-methyl-3,4-dihydro-β-carboline-3-carboxylic acid methyl ester as the major product in good yield.
Keywords :
4-dihydro-?-carboline-3-carboxylic acid , aromatization , 1-Methyl-3 , Oxidation , Chemoselective alkylation , N-Alkylation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
