Title of article :
Streamlined access to 2,3-dihydropyrazino[1,2-a]indole-1,4-diones via Ugi reaction followed by microwave-assisted cyclization
Author/Authors :
Tsirulnikov، نويسنده , , Sergey and Nikulnikov، نويسنده , , Mikhail and Kysil، نويسنده , , Volodymyr and Ivachtchenko، نويسنده , , Alexandre and Krasavin، نويسنده , , Mikhail، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
An efficient method is developed to construct drug-like 2,3-dihydropyrazino[1,2-a]indole-1,4-diones from 1H-indole-2-carboxylic acids, ethyl pyruvate, isocyanides, and primary amines via a one-pot, two-step procedure involving Ugi reaction and microwave-assisted cyclization.
Keywords :
Post-Ugi modifications , Combinatorial chemistry , Microwave-assisted synthesis , Isocyanide-based multi-component reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
