Title of article
Streamlined access to 2,3-dihydropyrazino[1,2-a]indole-1,4-diones via Ugi reaction followed by microwave-assisted cyclization
Author/Authors
Tsirulnikov، نويسنده , , Sergey and Nikulnikov، نويسنده , , Mikhail and Kysil، نويسنده , , Volodymyr and Ivachtchenko، نويسنده , , Alexandre and Krasavin، نويسنده , , Mikhail، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
5529
To page
5531
Abstract
An efficient method is developed to construct drug-like 2,3-dihydropyrazino[1,2-a]indole-1,4-diones from 1H-indole-2-carboxylic acids, ethyl pyruvate, isocyanides, and primary amines via a one-pot, two-step procedure involving Ugi reaction and microwave-assisted cyclization.
Keywords
Post-Ugi modifications , Combinatorial chemistry , Microwave-assisted synthesis , Isocyanide-based multi-component reactions
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1865958
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