Friedel–Crafts-type alkylation in aqueous media using resin-supported peptide catalyst having polyleucine

The asymmetric Friedel–Crafts-type alkylation in aqueous media was realized by the resin-supported N-terminal prolyl peptide catalyst having a polyleucine tether. The hydrophobic polyleucine chain in the peptide catalyst was essential for the reaction efficiency and enantioselectivity. The resin-bound peptide catalyst could be reused at least for five times.