Author/Authors :
Clark، نويسنده , , Andrew J. and Coles، نويسنده , , Stuart R. and Collis، نويسنده , , Alana and Debure، نويسنده , , Thomas and Guy، نويسنده , , Collette and Murphy، نويسنده , , Nicholas P. and Wilson، نويسنده , , Paul، نويسنده ,
Abstract :
Reaction of N-alkyl-N-(trichloroacetyl)arylsulfonamides with CuCl/amines leads to N-alkyl-N-(dichloroacetyl)-arylsulfonamides via reduction or N-alkyl-aryldichloroacetamides via 1,4-aryl migration with loss of SO2. The ratio of reduction to aryl migration is dependent upon the temperature and the ligand utilised. Along with amide bond hydrolysis these reactions may compete when carrying out slow atom transfer radical cyclisation reactions using sulfonamides.
Keywords :
Aryl migration , radical , Copper , ATRC
