Title of article
Facile and convenient strategy towards synthesis of 4-substituted 2-aminothiazolo[4,5-d]pyridazinones
Author/Authors
Sunil S. and Thorave، نويسنده , , Amol A. and Prajapati، نويسنده , , Pinkal N. and Pethani، نويسنده , , Jignesh P. and Kothari، نويسنده , , Krunal C. and Jain، نويسنده , , Mukul R. and Patel، نويسنده , , Pankaj R. and Kharul، نويسنده , , Rajendra K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
5660
To page
5663
Abstract
Convenient synthesis of 4-substituted 2-aminothiazolo[4,5-d]pyridazinones has been achieved in 12 steps with overall yield of 19% by employing Grignard reaction as the key step. The route utilizes well established thiazole ring formation followed by Grignard reaction to introduce substitution at 4-position effectively. In addition to the use of inexpensive chemicals, the present route first time gave access to the 4-substituted 2-aminothiazolo [4,5-d]pyridazinones with free amino group at C-2 position.
Keywords
Thiazole , cyclization , Hydrazine hydrate , N-Bromosuccinimide , 5-d]pyridazin-7(6H)-ones
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866050
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