Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).