Title of article :
First total syntheses and absolute configuration of rugulactone and 6(R)-(4′-oxopent-2′-enyl)-5,6-dihydro-2H-pyran-2-one
Author/Authors :
Mohapatra، نويسنده , , Debendra K. and Das، نويسنده , , Pragna P. and Sai Reddy، نويسنده , , D. and Yadav، نويسنده , , J.S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
The first efficient total syntheses of rugulactone and 6(R)-(4′-oxopent-2′-enyl)-5,6-dihydro-2H-pyran-2-one have been achieved in six steps with 51% and 48% overall yield, respectively. The key steps are Jacobsen’s hydrolytic kinetic resolution (HKR), Horner–Wadsworth–Emmons (HWE) homologation, and ring-closing metathesis reaction.
Keywords :
Rugulactone , ?-Pyranon-2-one , Jacobsen’s hydrolytic kinetic resolution , NF-?B inhibitors , ring-closing metathesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
