Title of article :
New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compounds
Author/Authors :
Gioiello، نويسنده , , Antimo and Khamidullina، نويسنده , , Asiya and Fulco، نويسنده , , Maria Carmela and Venturoni، نويسنده , , Francesco and Zlotsky، نويسنده , , Simon and Pellicciari، نويسنده , , Roberto، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A facile one-pot procedure for the synthesis of pyrazole-5-carboxylates by 1,3-dipolar cycloaddition of ethyl diazoacetate is described. Cycloadditions with α-methylene carbonyl compounds utilizing 1,8-diazabicyclo[5.4.0]undec-7-ene as base and acetonitrile as solvent provide pyrazoles with excellent regioselectivity and good yields. The reaction was found to proceed by a domino 1,3-dipolar cycloaddition-water elimination.
Keywords :
Ethyl diazoacetate , 1 , 3-dipolar cycloaddition , Pyrazole
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
