• Title of article

    An efficient synthesis of (R)- and (S)-baclofen via desymmetrization

  • Author/Authors

    Ji، نويسنده , , Lei and Ma، نويسنده , , Yuheng and Li، نويسنده , , Jin and Zhang، نويسنده , , Liangren and Zhang، نويسنده , , Lihe، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2009
  • Pages
    3
  • From page
    6166
  • To page
    6168
  • Abstract
    A short and highly enantioselective synthesis of both enantiomers of GABA agonist baclofen in four steps with total yields of 32.8% [for (S)-isomer] and 35.1% [for (R)-isomer] is reported. The key step involved desymmetrization of cyclic anhydride with modified cinchona alkaloids.
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2009
  • Journal title
    Tetrahedron Letters
  • Record number

    1866404

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1866404