Title of article
Preparation of 4-heteroaryl-4-cyanopiperidines via SNAr substitution reactions
Author/Authors
Chang، نويسنده , , Ronald K. and Di Marco، نويسنده , , Christina N. and Pitts، نويسنده , , Daniel R. and Greshock، نويسنده , , Thomas J. and Kuduk، نويسنده , , Scott D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
6303
To page
6306
Abstract
The scope and limitations of SNAr substitution reactions of metalated 4-cyanopiperidines with heterocyclic halides were explored. These facile reactions provide rapid access to a wide range of 4-heteroaryl-4-cyanopiperidines and have resulted in improved yields, faster reaction times, and lower temperatures than previously published synthetic methods.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866497
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