Title of article :
2-Aryl propionamides via 1,4-aryl radical migration from N-arylsulfonyl-2-bromopropionamides
Author/Authors :
Clark، نويسنده , , Andrew J. and Coles، نويسنده , , Stuart R. and Collis، نويسنده , , Alana and Fullaway، نويسنده , , David R. and Murphy، نويسنده , , Nicholas P. and Wilson، نويسنده , , Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
Reaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides via initial radical generation, 1,4-aryl migration with loss of SO2 and reduction of the intermediate amidyl radical in 40–99% yields.
Keywords :
radical , ATRC , Dimethylpiperazine , Copper , atom transfer , Aryl migration
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
