Title of article
Improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one, a building block for γ-secretase inhibitors
Author/Authors
Hoffmann-Emery، نويسنده , , Fabienne and Jakob-Roetne، نويسنده , , Roland and Flohr، نويسنده , , Alexander and Bliss، نويسنده , , Fritz and Reents، نويسنده , , Reinhard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
6380
To page
6382
Abstract
An improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one (1), involving a selective crystallization of epimeric menthylcarbamates for the resolution step followed by simultaneous cleavage of the carbamate and the lactam protecting group is described. Epimerization conditions of the undesired epimer have also been determined.
Keywords
Menthylcarbamate , Aminodibenzoazepinone , Epimerization , RESOLUTION , Diastereoselective crystallization
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866560
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