Title of article
An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol
Author/Authors
Kim، نويسنده , , Sung-Hwan and Lee، نويسنده , , Hyun Seung and Kim، نويسنده , , Ko Hoon and Kim، نويسنده , , Jae Nyoung، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
6476
To page
6479
Abstract
We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from δ-ketonitriles. Initial attack of allylindium species occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines.
Keywords
Indium , Isoquinolines , Barbier reaction , ?-Ketonitriles
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866620
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