Title of article :
Photoinduced DNA cleavage by fullerene–lysine conjugate
Author/Authors :
Kumar، نويسنده , , Anish and Rao، نويسنده , , Mandava V. and Menon، نويسنده , , Shobhana K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
A novel water-soluble [60] fullerene-substituted lysine derivative 3 has been synthesized and characterized by elemental analysis, 1H NMR, 13C NMR and FAB-MS. The synthetic procedure involved condensation of Boc-protected lysine with terephthaldehyde followed by 1,3-dipolar cycloaddition reaction with C60 in the presence of sarcosine and finally deprotection of the amino group using trifluoroacetic acid. The synthesized compound 3 exhibited high DNA cleavage efficiency upon visible light irradiation in the presence of NADH.
Keywords :
DNA cleavage , Lysine , 3 Dipolar cycloaddition reaction , 1 , Fullerene
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
