Title of article
A simple one-pot synthesis of triflyl guanidines: access to highly substituted electron-poor guanidines
Author/Authors
Thai، نويسنده , , Karen and Clement، نويسنده , , Craig W. and Gravel، نويسنده , , Michel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
6540
To page
6542
Abstract
Unsymmetrical di- and trisubstituted triflyl guanidines are accessed through a simple, one-pot protocol from the corresponding isothiocyanate and amine. Furthermore, in the presence of base, trisubstituted triflyl guanidines are alkylated to obtain tetrasubstituted triflyl guanidines in high yields and complete regioselectivity.
Keywords
Isothiocyanates , regioselective alkylation , Guanidines , Trifluoromethanesulfonamide
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866676
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