Title of article
Studying the reactivity of (phthalazin-1(2H)-on-2-yl)methyl trichloroacetimidate towards different C- and O-nucleophiles
Author/Authors
El Nezhawy، نويسنده , , Ahmed O.H. and Gaballah، نويسنده , , Samir T. and Radwan، نويسنده , , Mohamed A.A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
5
From page
6646
To page
6650
Abstract
A simple and efficient synthesis of phthalazin-1(2H)-one 2-substituted derivatives is achieved in very good yields via reaction of a phthalazinone–trichloroacetimidate with various C- and O-nucleophiles such as aromatic, heteroaromatic and olefinic reagents, sugars and cholesterol in CH2Cl2 in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate (TMSOTf).
Keywords
trichloroacetimidate , O-nucleophiles , C-nucleophiles , Trimethylsilyl trifluoromethanesulfonate (TMSOTf) , N-Phthalazinone
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1866746
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