Author/Authors :
Shakiru O. Alapafuja، نويسنده , , Shakiru O. and Nikas، نويسنده , , Spyros P. and Shukla، نويسنده , , Vidyanand G. and Papanastasiou، نويسنده , , Ioannis and Makriyannis، نويسنده , , Alexandros، نويسنده ,
Abstract :
We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase.
Keywords :
Sodium sulfonates , microwave , sulfonyl chlorides , Sulfonyl fluorides
