Author/Authors :
Gaëlle Fourrière، نويسنده , , Gaëlle and Lalot، نويسنده , , Jérôme and Hijfte، نويسنده , , Nathalie Van and Quirion، نويسنده , , Jean-Charles and Leclerc، نويسنده , , Eric، نويسنده ,
Abstract :
The synthesis of difluorinated carbocyclic analogues of 5-deoxypentofuranoses is described. The sequence involves an addition of PhSeCF2TMS to carbohydrate-derived aldehydes followed by a radical cyclization, and provides a secure strategy for a future synthesis of pentofuranoses and nucleoside analogues.
Keywords :
nucleosides , Carbasugars , radical cyclization , fluorine
