Title of article
Facile synthesis of (−)-6-acetoxy-5-hexadecanolide by size-selective ring-closing/cross metathesis
Author/Authors
Quinn، نويسنده , , Kevin J. and Curto، نويسنده , , John M. and McGrath، نويسنده , , Kevin P. and Biddick، نويسنده , , Neal A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
7121
To page
7123
Abstract
A total synthesis of (−)-6-acetoxy-5-hexadecanolide, in six steps and 37% overall yield from (2R,3S)-1,2-epoxy-4-penten-3-ol is reported. The key synthetic step is a size-selective ring-closing/cross metathesis reaction in which lactone formation and alkyl chain extension are accomplished in an efficient one-pot process.
Keywords
heterocycle synthesis , Olefin metathesis , Ring-size selectivity
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1867104
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