Title of article
Synthesis of 4,5-disubstituted-3-trihalomethylisothiazoles
Author/Authors
Zawistoski، نويسنده , , Michael P. and Decker، نويسنده , , Shannon M. and Griffith، نويسنده , , David A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
2
From page
7286
To page
7287
Abstract
Herein, we describe the synthesis of 4,5-disubstituted-3-trihalomethylisothiazoles from trihaloacetonitriles and 2-cyanothioacetamides or 2-ethoxycarbonylthioacetamides. The reactivity of the necessary trihaloacetonitriles has a significant impact on the observed reaction pathways. Reactions with CF3CN require an oxidant to mediate cyclization, while CCl3CN functions as both the reactant and oxidant.
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1867225
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