Title of article
Immobilized microorganisms in the reduction of ethyl benzoylacetate
Author/Authors
Ramos، نويسنده , , Aline de Souza and Ribeiro، نويسنده , , Joyce Benzaquem and Vazquez، نويسنده , , Leonardo and Fiaux، نويسنده , , Sorele Batista and Leite، نويسنده , , Selma Gomes Ferreira and Ramos، نويسنده , , Maria da Conceiçمo Klaus V. and Neto، نويسنده , , Francisco Radler de Aquino and Antunes، نويسنده , , O.A.C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
3
From page
7362
To page
7364
Abstract
The enantioselective reduction of ethyl benzoylacetate (EBA) into ethyl (S)-3-hydroxy-3-phenylpropanoate (S-HPPE) by nine yeast strains and three filamentous fungi strains is described. The conversion obtained was in the range 0–89% and the enantiomeric excess was 100% in many cases. Conversion levels were higher when the reduction was performed with microorganisms immobilized in calcium alginate and enantioselectivity remained excellent. Some reaction’s conditions of bioreduction by immobilized cells of Rhodotorula rubra were studied using a 25-2 fractional factorial design.
Keywords
?-Ketoester , Immobilization , Rhodotorula rubra , chiral reduction
Journal title
Tetrahedron Letters
Serial Year
2009
Journal title
Tetrahedron Letters
Record number
1867289
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