Title of article :
Formal total synthesis of (−)-balanol: a potent PKC inhibitor
Author/Authors :
Yaragorla، نويسنده , , Srinivasarao and Muthyala، نويسنده , , Ramaiah، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
An efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from the commercially available pentane1,5-diol. A Shi epoxidation and Pd(0)-mediated nitrogen substitution with double inversion established the correct configuration of the balanol precursor 3.
Keywords :
PKC inhibitors , Triphenyl phosphine mediated rearrangement , Pd(PPh3)4-mediated epoxide opening , Shi epoxidation , balanol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
