Author/Authors :
Kureshy، نويسنده , , Rukhsana I. and Agrawal، نويسنده , , Santosh and Saravanan، نويسنده , , S. and Khan، نويسنده , , Noor-ul H. and Shah، نويسنده , , Arpan K. and Abdi، نويسنده , , Sayed H.R. and Bajaj، نويسنده , , Hari C. and Suresh، نويسنده , , E.، نويسنده ,
Abstract :
Fe(Cp)2PF6 (5 mol %) efficiently catalyzed Mannich reaction of aldehydes, anilines, and ketones under solvent-free condition to give β-amino-ketones in high yield (up to 94%) within 30 min with anti-isomer in excess. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones.
Keywords :
Mannich reaction , carbonyl compounds , solvent-free synthesis , Catalysis , Fe(Cp)2PF6
